Alex Bussenger, Founder & Managing Partner

January 2025​

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Our Investment in Nucleus: The Future of Personalized and Preventative Healthcare

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We are excited to announce our investment in Nucleus, which delivers the most comprehensive look into health and well-being that’s ever been available. As we continue to back the companies shaping the future of preventative and personalized healthcare, Nucleus represents a fundamental shift in how individuals understand and manage their health.

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Introduction

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"Knowing yourself is the beginning of all wisdom." - Aristotle​

 

Aristotle’s wisdom is more relevant than ever in the age of personalized medicine. For centuries, understanding oneself has been viewed as the foundation for making better decisions. Today, this principle can be applied on a biological level through advancements in genomics.

 

Our investment in Nucleus is based on this very idea: when individuals truly understand themselves - at the deepest genetic level - they can make smarter, more proactive decisions about their health and well-being. 

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Today, knowing oneself isn’t just a philosophy - it’s a science that can help people live longer, healthier lives.​

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The Future of Healthcare: From One-Size-Fits-All to Deep Personalization

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For too long, healthcare has been built around reactive care, treating disease only after symptoms appear. However, the future of healthcare will be defined by a shift away from one-size-fits-all approaches toward deeply personalized, data-driven systems. This evolution is powered by advancements in genetics, AI, and real-time health data, allowing individuals to:

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• Detect risks early before conditions develop.

• Tailor treatments to their genetic profile for greater effectiveness.

• Optimize lifestyle choices based on precise, personalized insights.

 

This transformation reduces the burden on reactive care systems while empowering individuals to take greater control of their well-being. 

 

Nucleus is at the forefront of this shift.

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Why We Invested 

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Nucleus offers an all-in-one DNA health test that uncovers genetic risk for 800+ conditions. Unlike traditional genetic reports that provide limited insights, Nucleus delivers an unprecedented depth of data, enabling truly actionable healthcare decisions.

 

Beyond the technology, our conviction in Nucleus was solidified through conversations with its founder and CEO, Kian Sadeghi. From our very first discussion, his relentless drive to transform healthcare was undeniable. We were both shaped by personal experiences that made our missions deeply meaningful - turning life’s challenges into a commitment to create lasting impact.

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A Transformational Moment in Healthcare

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Preventative and personalized healthcare is no longer just a vision - it’s happening now. We are honored to join Nucleus’ Series A round alongside Alexis Ohanian and 776, Founders Fund, and others.

 

At One Eight Capital, we believe the future belongs to those who redefine healthcare through innovation, data, and empowerment. Our investment in Nucleus is a testament to this belief, and we couldn’t be more excited for what’s ahead.

 

The next era of healthcare starts here.

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How It Works

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1) Order your kit - free shipping to your home

2) Collect your DNA sample - swab your cheek

3) Send your sample back to the lab - get your results* and clarity on your health risks in 4-6 weeks with easy-to-read reports 

 

*Your Nucleus results include personalized insights about how your unique DNA combines with your lifestyle factors to influence your disease risks and trait dispositions.